Resident and recruited macrophages polarize into M1 and M2 subtypes, two extremes in a continuum of polarization states. We introduced the role of ROCK signaling in macrophage polarization. The rho-associated, coiled–coil–containing protein kinases (ROCKs) are cytosolic signaling molecules that contribute to cytoskeletal functions and contractility. ROCK has been a recent target in glaucoma, since ROCK inhibition improves the outflow in the trabecular meshwork. The relevance of the new link between ROCK signaling and macrophage polarization in eye diseases is subject of our current investigations.